Research Opportunity 

Efficacy and Safety of Rezafungin, Ibrexafungerp, and Fosmanogepix for Invasive Candidiasis: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

This systematic review and network meta-analysis evaluates the efficacy and safety of rezafungin, ibrexafungerp, and fosmanogepix for the treatment of invasive candidiasis, comparing their clinical outcomes and adverse event profiles across randomized controlled trials.

 Available : Open
Deadline : July 04, 2026

Incidental Pulmonary Nodules Detected on Emergency Department Computed Tomography Scans: A Scoping Review of Follow-Up Adherence, Management Pathways, and Clinical Outcomes

This scoping review aims to assess adherence to recommended follow-up for incidental pulmonary nodules detected on emergency department CT scans and evaluate the referral pathways and outcomes associated with delayed or missed follow-up.

 Available : Open
Deadline : July 04, 2026

Controlled Attenuation Parameter and Magnetic Resonance Elastography for Monitoring Fibrosis Regression in MASLD Patients With Severe Obesity Undergoing Incretin-Based Therapy: A Systematic Review and Meta-Analysis

This systematic review and meta-analysis evaluates the utility of controlled attenuation parameter (CAP) and magnetic resonance elastography (MRE) for monitoring fibrosis regression in MASLD patients with severe obesity receiving incretin-based therapy.

 Available : Open
Deadline : July 04, 2026

Serial Cardiac Biomarkers and Strain Echocardiography for Early Detection of Immune Checkpoint Inhibitor-Induced Myocarditis: A Systematic Review and Diagnostic Test Accuracy Meta-Analysis

This systematic review and diagnostic test accuracy meta-analysis evaluates the performance of serial cardiac biomarkers and strain echocardiography for the early detection of immune checkpoint inhibitor-induced myocarditis.

 Available : Open
Deadline : July 04, 2026

Artificial Intelligence Algorithms Utilizing Multi-Spectral and Ultraviolet-Induced Fluorescence Dermoscopy for Skin Cancer Detection: A Systematic Review and Diagnostic Test Accuracy Meta- Analysis

This systematic review and diagnostic test accuracy meta-analysis evaluates the performance of artificial intelligence algorithms using multispectral and ultraviolet-induced fluorescence dermoscopy for skin cancer detection.

 Available : Open
Deadline : July 04, 2026

Gut Microbiota-Derived Short-Chain Fatty Acids and Bile Acid Metabolites for Predicting Response and Toxicity to Immune Checkpoint Inhibitors in Colorectal Cancer: A Systematic Review and Meta- Analysis

This systematic review and meta-analysis evaluates the role of gut microbiota-derived short-chain fatty acids and bile acid metabolites in predicting treatment response and toxicity to immune checkpoint inhibitors in colorectal cancer patients.

 Available : Open
Deadline : July 04, 2026

Explainability Frameworks and Methodological Rigor of Machine Learning Models for Stroke Outcome Prediction: A Systematic Review and Meta-Analysis of Predictive Performance

This systematic review and meta-analysis evaluates the explainability frameworks, methodological rigor, and predictive performance of machine learning models for stroke outcome prediction, assessing their accuracy and clinical applicability.

 Available : Open
Deadline : July 04, 2026

Sarcopenic Obesity in Chronic Kidney Disease: Prevalence, Clinical Characteristics, and Associations With Mortality and Adverse Clinical Outcomes A Systematic Review and Meta-Analysis

This systematic review and meta-analysis will assess the prevalence of sarcopenic obesity in patients with chronic kidney disease and evaluate its association with mortality and adverse clinical outcomes.

 Available : Open
Deadline : July 04, 2026

Artificial Intelligence Algorithms for Quantitative Immunohistochemistry Scoring and Tumor- Infiltrating Lymphocyte Segmentation in Solid Tumors: A Systematic Review and Diagnostic Agreement Meta-Analysis

This systematic review and diagnostic agreement meta-analysis evaluates the performance of artificial intelligence algorithms for quantitative immunohistochemistry scoring and tumor-infiltrating lymphocyte segmentation in solid tumors.

 Available : Open
Deadline : July 04, 2026

Residual Ductal Carcinoma In Situ After Neoadjuvant Chemotherapy and Risk of Local Recurrence in Triple-Negative Breast Cancer: A Systematic Review and Meta-Analysis

This systematic review and meta-analysis synthesizes current evidence on the prognostic impact of residual ductal carcinoma in situ (DCIS) following neoadjuvant chemotherapy in triple-negative breast cancer.

 Available : Open
Deadline : July 04, 2026

Assessment Tools and Monitoring Strategies for Pediatric Delirium in the PICU: A Scoping Review

This scoping review will examine the literature on assessment tools and monitoring strategies for pediatric delirium in the PICU, focusing on screening methods, implementation practices, and reported diagnostic performance across critically ill pediatric populations.

 Available : Open
Deadline : July 04, 2026

Machine Learning Models for Predicting 30-Day Hospital Readmission Following Acute Exacerbation of COPD: A Systematic Review

This systematic review evaluates the predictive performance and clinical applicability of machine learning models for predicting 30-day hospital readmission following acute exacerbation of chronic obstructive pulmonary disease (COPD).

 Available : Open
Deadline : July 04, 2026

Cardiovascular Remodeling and Myocardial Fibrosis Outcomes of Dual GIP/GLP-1 Receptor Agonism With Tirzepatide in Obesity and Heart Failure: A Systematic Review and Meta-Analysis of Clinical Trials

This systematic review and meta-analysis evaluates the effects of tirzepatide on cardiovascular remodeling, myocardial fibrosis, and heart failure outcomes in patients with obesity, aiming to assess its potential cardiovascular benefits beyond weight reduction.

 Available : Open
Deadline : July 04, 2026

MRI Manifestations Across the Spectrum of Gluten-Related Disorders: A Scoping Review of Extra-Intestinal Findings

This scoping review will map MRI findings reported in gluten ataxia and related gluten-associated neurological disorders, including cerebellar atrophy, white matter changes, and other structural abnormalities linked to neurological dysfunction.

 Available : Open
Deadline : July 04, 2026

Perioperative Dexmedetomidine for Reduction of Postoperative Opioid Consumption: An Umbrella Review of Systematic Reviews and Meta-Analyses

This umbrella review will synthesize systematic reviews and meta-analyses evaluating perioperative dexmedetomidine for opioid-sparing postoperative analgesia, focusing on postoperative opioid consumption, pain control, and related clinical outcomes.

 Available : Open
Deadline : July 04, 2026

Global Research Trends in Metal Hypersensitivity Following Joint Arthroplasty: A Bibliometric and Knowledge-Mapping Analysis

This bibliometric study will analyze the scientific literature on metal hypersensitivity following joint arthroplasty, focusing on publication trends, influential contributors, and emerging research themes related to implant materials, allergy testing, and revision surgery.

 Available : Open
Deadline : July 04, 2026

Diagnostic Equivalency of Arterial Spin Labeling and Synthetic MRI Versus Contrast-Enhanced MRI in Pediatric Neuroimaging: A Systematic Review and Concordance Analysis

This systematic review and concordance analysis evaluates the diagnostic equivalency of arterial spin labeling and synthetic MRI compared with contrast-enhanced MRI in pediatric neuroimaging, assessing their potential as non-contrast imaging alternatives.

 Available : Open
Deadline : July 04, 2026

PDE-4 Inhibitor Therapy for Inflammatory Dermatologic Diseases: A Bibliometric and Knowledge-Mapping Analysis

This bibliometric study will analyze the scientific literature on PDE-4 inhibitor therapy in inflammatory dermatologic diseases, focusing on publication trends, influential contributors, and emerging research themes across conditions such as psoriasis and atopic dermatitis.

 Available : Open
Deadline : July 04, 2026

Sleep and Circadian-Based Interventions for Major Depressive Disorder: An Umbrella Review of Systematic Reviews and Meta-Analyses

This umbrella review will synthesize evidence from systematic reviews and meta-analyses on sleep- and circadian-based interventions for major depressive disorder, focusing on their effects on depressive symptoms and treatment outcomes.

 Available : Open
Deadline : July 04, 2026

Intravenous Lidocaine Infusion Versus Thoracic Epidural Analgesia for Postoperative Recovery and Opioid Sparing in Pediatric Major Scoliosis Surgery: A Systematic Review

This systematic review evaluates the efficacy and safety of intravenous lidocaine infusion versus thoracic epidural analgesia for improving postoperative recovery and reducing opioid use following pediatric major scoliosis surgery.

 Available : Open
Deadline : July 04, 2026